Accord study results ppt

Effects of Intensive Glucose Lowering in Type 2 Diabetes ...

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Regardless of the results of these other trials, our study has identified a previously unrecognized harm of intensive glucose lowering in high-risk patients with type 2 diabetes mellitus and high ...

Effects of Intensive Glucose Lowering in Type 2 Diabetes ...

Effects of Intensive Blood-Pressure Control in Type 2 ...

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Study Design. ACCORD was a randomized trial conducted at 77 clinical sites organized into seven networks in the United States and Canada (for a full list of participating institutions and ...

Effects of Intensive Blood-Pressure Control in Type 2 ...

The ACCORD Trial: Rationale and Results - Medscape

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ACCORD Eye Study In addition, there was another substudy of the ACCORD trial called the ACCORD Eye study, which took a small subgroup of patients and looked at factors that contributed toward progression of diabetic retinopathy. And in this trial there was a positive result with a 33% reduction in progression of retinopathy in patients who were ...

The ACCORD Trial: Rationale and Results - Medscape

Glycemia Intervention Data Report - Clinical Trial Results

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William C. Cushman, MD, FACP, FAHA Veterans Affairs Medical Center, Memphis, TN For The ACCORD Study Group * * * * * * * ACCORD Sponsor, Collaborators and Contributors Collaboration & support National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) National Eye Institute (NEI) National Institute on Aging (NIA) Centers for Disease Control and Prevention (CDC) Sponsor: …

Glycemia Intervention Data Report - Clinical Trial Results

(ACCORD) Action to Control Cardiovascular Risk in Diabetes

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ACCORD Data and Biospecimens. The ACCORD Study Data and Biospecimens are now available in the NHLBI Biological Specimen and Data Repository Information Coordinating Center (BioLINCC) Overview of ACCORD and ACCORDION. Patients with type 2 diabetes mellitus die of cardiovascular disease (CVD) at rates two to four times higher than non-diabetic ...

(ACCORD) Action to Control Cardiovascular Risk in Diabetes

Clinical Implications of the ACCORD Trial | The Journal of ...

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1/1/2012 · The Action to Control Cardiovascular Disease in Diabetes (ACCORD) study has completed its full 5-yr planned follow-up, and all main results have been published (1–4). It is therefore now appropriate to take stock and consider the clinical implications of these results.

Clinical Implications of the ACCORD Trial | The Journal of ...

Landmark ACCORD Trial Finds Intensive Blood Pressure and ...

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The results of the ACCORD blood pressure and lipid clinical trials appear online in the New England Journal of Medicine (NEJM) today and will be in the April 29, 2010, NEJM print edition. The results are also being presented today at the American College of Cardiology’s 59th annual scientific session in …

Landmark ACCORD Trial Finds Intensive Blood Pressure and ...

The ACCORD (Action to Control Cardiovascular Risk in ...

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5/1/2011 · Department of Medicine and the Irving Institute for Clinical and Translational Research, Columbia University College of Physicians and Surgeons, New York, New York ↵Corresponding author: Henry N. Ginsberg, hng1atcolumbia.edu. ACCORD (Action to …

The ACCORD (Action to Control Cardiovascular Risk in ...

Action to Control Cardiovascular Risk in Diabetes (ACCORD ...

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Action to Control Cardiovascular Risk in Diabetes Follow-On (ACCORDION) Eye Study Group and the Action to Control Cardiovascular Risk in Diabetes Follow-On (ACCORDION) Study Group. Persistent Effects of Intensive Glycemic Control on Retinopathy in Type 2 Diabetes in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Follow-On Study.

Action to Control Cardiovascular Risk in Diabetes (ACCORD ...

PPT - Summary of ACCORD, ADVANCE, and VADT Trials ...

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Summary of ACCORD, ADVANCE, and VADT Trials. ACCORD - Action to Control Cardiovascular Risk in Diabetes ADVANCE - Action in Diabetes to Prevent Vascular Disease VADT - Veterans Administration Diabetes Trail. Stephen Rith-Najarian, Diabetes Consultant Bemidji Area IHS. Slideshow 5015562...

PPT - Summary of ACCORD, ADVANCE, and VADT Trials ...

ACCORD, ADVANCE, and the VADT: What Do They ... - diaTribe

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The ACCORD BP study shows that there is no benefit to be gained from intensively lowering systolic blood pressure to less than 120 mm Hg in type 2 diabetics; for now, a goal of <140 mm Hg seems ...

ACCORD, ADVANCE, and the VADT: What Do They ... - diaTribe

ACCORD BP: Intensive BP Lowering Futile in ... - Medscape

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A Summary of the ADVANCE Trial. Simon R. Heller, DM, ... the results, published in The Lancet in 2007 , ... The ADVANCE study also included a large group of individuals from Asia whose diabetes might be expected to behave differently from a U.K. population. However, preliminary analyses do not suggest that the European patients in ADVANCE ...

ACCORD BP: Intensive BP Lowering Futile in ... - Medscape

A Summary of the ADVANCE Trial - PubMed Central (PMC)

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ACCORD Clinical Trial Publishes Results. ... and other outcomes in the study participants. ACCORD is primarily funded by NHLBI, with additional funding and scientific expertise contributed by the National Institute of Diabetes and Digestive and Kidney Diseases. Other components of the NIH — the National Institute of Aging and National Eye ...

A Summary of the ADVANCE Trial - PubMed Central (PMC)

ACCORD Clinical Trial Publishes Results, June 6, 2008 ...

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CONCLUSIONS Prior intensive glycemic control continued to reduce diabetic retinopathy progression, despite similar A1C levels, when the ACCORD Study ended. This is the first study in people with type 2 diabetes of 10 years’ duration and established cardiovascular disease, unlike the newly diagnosed participants of the UK Prospective Diabetes Study, to demonstrate this effect.

ACCORD Clinical Trial Publishes Results, June 6, 2008 ...

Persistent Effects of Intensive Glycemic ... - Diabetes Care

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In ACCORD, the mean triglyceride level in the overall study was just 162 mg/dL. One clinician surprised by the results, however, is Dr Roger Blumenthal (Johns Hopkins Medical Center, Baltimore, MD).

Persistent Effects of Intensive Glycemic ... - Diabetes Care

ACCORD Lipid Study - Medscape

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6/6/2008 · The ACCORD and ADVANCE Trials: Implications for Patients with Type 2 Diabetes Harlan M. Krumholz, MD, SM reviewing Patel A et al. for the ADVANCE Collaborative Group. N Engl J Med 2008 Jun 6 Gerstein HC et al. for the Action to Control Cardiovascular Risk in Diabetes Study Group.

ACCORD Lipid Study - Medscape

The ACCORD and ADVANCE Trials: Implications for Patients ...

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About 126 patients at NY Harbor are eligible to participate in ACCORDION and 41 are eligible for the Eye Sub-study. ACCORD participants who agree to participate in ACCORDION will be followed through clinic and phone visits for about 3.5 years from 2011 through 2014. This will provide approximately 10 years of post-randomization follow-up.

The ACCORD and ADVANCE Trials: Implications for Patients ...

ACCORDION: the ACCORD Follow-on Study | Division of Nephrology

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7/27/2012 · A randomized study on Action to Control Cardiovascular Risk in Diabetes (ACCORD Lipid) to test whether the treatment of blood lipids with a fibrate plus a statin can reduce the risk of major CVD events in patients with type 2 diabetes who are at especially high risk of CVD

ACCORDION: the ACCORD Follow-on Study | Division of Nephrology

ACCORD Lipid trial - Summary & Results - SlideShare

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Explanation for the ACCORD outcomes? Matthew C. Riddle, MD ... The ACCORD Study Group. N Engl J Med. 2008;358:2545 –2559 . Characteristics of participants in ACCORD . ... ACCORD Glucose Study: 5-year results . Increased all-cause and CV mortality . Unadjusted HR for p-value .

ACCORD Lipid trial - Summary & Results - SlideShare

Explanation for the ACCORD outcomes? - Denver, Colorado

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None of the materials on this website may be reproduced, modified, distributed, transmitted, republished, displayed, or performed unless prior written approval is obtained by Clinical Trial Results. All such requests should be forwarded to Susan J. Marble at smarble@clinicaltrialresults.org .

Explanation for the ACCORD outcomes? - Denver, Colorado

Clinical Trial Results: The International Leader in ...

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study participants with an average CVD risk of 2% per year, ≈ ... the ACCORD results, the primary CVD outcome was 26% lower in participants randomized to the intensive BP and stan-dard glycemia goals than in those assigned to the combined standard BP and glycemia treatment goals.4 Such a benefit is

Clinical Trial Results: The International Leader in ...

SPRINT Trial Results - ahajournals.org

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3/15/1999 · The UK Prospective Diabetes Study (UKPDS): clinical and therapeutic implications for type 2 diabetes. Paromita King, 1 Ian Peacock, 1 and Richard Donnelly 1, 2 ... This is reassuring in implementing the results of the study, though the results may not apply equally to an unselected population.

SPRINT Trial Results - ahajournals.org

The UK Prospective Diabetes Study (UKPDS): clinical and ...

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A placebo is an injection, infusion or pill that seems identical to the new treatment, but is actually inactive. Comparative studies are typically conducted as double-blind trials, where neither the physician nor the patient knows which group is receiving the new drug. Double …

The UK Prospective Diabetes Study (UKPDS): clinical and ...

Types of Clinical Trials - Accord Clinical Research

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Systolic Blood Pressure Response in SPRINT (Systolic Blood Pressure Intervention Trial) and ACCORD (Action to Control Cardiovascular Risk in Diabetes): A Possible Explanation for Discordant Trial Results. Chenxi Huang, Sanket S. Dhruva, Andreas C. Coppi, Frederick Warner, Shu‐Xia Li, …

Types of Clinical Trials - Accord Clinical Research

SPRINT Trial Results | Hypertension

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The NIDDK funded the landmark Diabetes Control and Complications Trial (DCCT) to see if people with type 1 diabetes who kept their blood glucose levels as close to normal as safely possible with intensive diabetes treatment (3 or more shots of insulin per day or an insulin pump with self-monitoring ...

SPRINT Trial Results | Hypertension

Blood Glucose Control Studies for Type 1 Diabetes: DCCT ...

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12/15/2009 · Mahaffey KW, Neal B, Perkovic V, de Zeeuw D, Fulcher G, Erondu N, Shaw W, Fabbrini E, Sun T, Li Q, Desai M, Matthews DR; CANVAS Program Collaborative Group. Canagliflozin for Primary and Secondary Prevention of Cardiovascular Events: Results From the CANVAS Program (Canagliflozin Cardiovascular Assessment Study).

Blood Glucose Control Studies for Type 1 Diabetes: DCCT ...

CANVAS - CANagliflozin cardioVascular Assessment Study ...

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8/7/2012 · ACCORD BP: Results• No significant difference in the primary end point as well as in the prespecified secondary end points between the groupsPrimary and secondary outcomesa Outcome Intensive therapy Intensive therapy Standard therapy Standard therapy Hazard p (n=2363), events, n (n=2363), %/y (n=2371), events, n (n=2371), %/y ratio Primary ...

CANVAS - CANagliflozin cardioVascular Assessment Study ...

ACCORD BP trial - Summary & Results - SlideShare

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In view of the superior benefits of the lower blood pressure treatment intervention, the DSMB recommended communicating these results to study participants, investigators, and the public. The NHLBI accepted this recommendation and ended the blood pressure intervention of the SPRINT study about a year in advance of the original trial end date.

ACCORD BP trial - Summary & Results - SlideShare

Systolic Blood Pressure Intervention Trial (SPRINT) Study ...

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9/8/2017 · > PURE study makes headlines, but the conclusions are misleading. The Nutrition Source expand child menu. Search for: Home; ... PURE study makes headlines, but the conclusions are misleading. Click to share on Facebook (Opens in new window) ... The Lancet published results from the Prospective Urban Rural Epidemiology (“PURE”) study that ...

Systolic Blood Pressure Intervention Trial (SPRINT) Study ...

PURE study makes headlines, but the conclusions are ...

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- Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) The ALLHAT blood pressure trial Participants had high blood pressure and at least one other risk factor for heart disease, such as cigarette smoking or type 2 diabetes.

PURE study makes headlines, but the conclusions are ...

Antihypertensive and Lipid-Lowering Treatment to Prevent ...

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The ACCORD, ADVANCE, and VADT trial all continued longer term follow up and published extended results (15,16, 18), but this yielded little new information. All trials agreed that intensive treatment did not save lives and had marginal benefits if any. Furthermore, there were adverse health consequences.

Antihypertensive and Lipid-Lowering Treatment to Prevent ...

ACCORD/ADVANCE/VADT/ORIGIN/TECOS - T2D 39 - Intensive ...

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6/13/2016 · Results from ACCORDION suggest that lowering blood glucose can reduce progression of retinal disease relatively late in the course of type 2 diabetes and that even short-term changes in glucose ...

ACCORD/ADVANCE/VADT/ORIGIN/TECOS - T2D 39 - Intensive ...

ACCORDION study shows lowering blood glucose can reduce ...

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SPRINT is a two-arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure to a lower goal than currently recommended will reduce cardiovascular disease risk.

ACCORDION study shows lowering blood glucose can reduce ...

sprint

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4/18/2013 · The study was a double-blind randomised trial undertaken at 204 centres in 25 countries. Patients with HER2-positive metastatic breast cancer who had not received previous chemotherapy or biological treatment for their metastatic disease were randomly assigned to receive either pertuzumab, trastuzumab, and docetaxel (n=402) or the same regimen with a matching placebo replacing …

sprint

Pertuzumab, trastuzumab, and docetaxel for HER2-positive ...

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Phase III Trials. Very few new drugs ever make it past Phase II research.In fact, only 1/3 of drugs ever make it to Phase III clinical trials. The drugs that progress to Phase III are definitively tested for effectiveness in the treatment or cure of a specific condition.

Pertuzumab, trastuzumab, and docetaxel for HER2-positive ...

Phase III Clinical Trials - Accord Clinical Research

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The outcome of this study is surprising as other drugs that inhibit the Renin-Angiotensin System (RAS) decrease the incidence of hypertension (a surrogate endpoint) as well as the rate of strokes and cardiovascular deaths. These results emphasize the importance of hard endpoints such as death, because surrogate endpoints can be misleading.

Phase III Clinical Trials - Accord Clinical Research

The ALTITUDE trial: Aliskiren increases the risk of ...

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6/4/2016 · Diabetes health care professionals have to face a study with results of incomparable success in secondary and tertiary cardiovascular disease prevention. In the past, no studies in patients with type 2 diabetes resulted to be successful in inducing an improvement of cardiovascular prognosis, no matter whether they were focused on a target, on life-style or on pharmacological intervention.

The ALTITUDE trial: Aliskiren increases the risk of ...

The EMPA-REG outcome study: critical appraisal and ...

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FCCC/CP/2015/L.9 3 7. Decides to establish the Ad Hoc Working Group on the Paris Agreement under the same arrangement, mutatis mutandis, as those concerning the election of officers to the Bureau of the Ad Hoc Working Group on the Durban Platform for Enhanced Action;1 8.

The EMPA-REG outcome study: critical appraisal and ...

ADOPTION OF THE PARIS AGREEMENT - UNFCCC

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ACCORD Study Design ACCORD BP Trial Eligibility ACCORD Double 2 x 2 Factorial Design ACCORD BP Trial Results ACCORDION BP 3957 (87%) surviving ACCORD BP Participants consented to post-trial follow-up of up to 60 months Phone or clinic contacts every 6 months for CVD event follow-up 3 clinic visits 24-30 months, 36-48 months, and 54-60 months ...

ADOPTION OF THE PARIS AGREEMENT - UNFCCC

Glycemia Intervention Data Report - acc.org

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The results of the SPRINT study were revealed at the AHA Scientific Sessions on November 9th. A few months’ earlier, the study was stopped prematurely, with a press release indicating a highly significant positive outcome. As a result, the presentation during AHA 2015 held few surprises. SPRINT is almost the mirror image of a previous trial ...

Glycemia Intervention Data Report - acc.org

SPRINT Trial Hub - American College of Cardiology

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Reporting and discussing your findings; Reporting and discussing your findings. This page deals with the central part of the thesis, where you present the data that forms the basis of your investigation, shaped by the way you have thought about it. In other words, you tell …

SPRINT Trial Hub - American College of Cardiology

Reporting and discussing your findings - Research ...

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Basel II Pillar II Practice Study The World Bank By Ana María Avilés Washington DC –October 22, 2018. Outline 1. ... Basel II Framework The 1988 Accord (Basel I) was the first standard agreed on to establish common capital requirements for internationally active banks. II Pillar I ... satisfactory ICAAP results

Reporting and discussing your findings - Research ...

Basel II Pillar II Practice Study - pubdocs.worldbank.org

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http://www.theheart.org/web_slides/1145575.do A randomized study on Action to Control Cardiovascular Risk in Diabetes (ACCORD Lipid) to test whether the treatm…

Basel II Pillar II Practice Study - pubdocs.worldbank.org

ACCORD Lipid trial - Summary & Results - fr.slideshare.net

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Design Decisions in Research. 1. Learning Objectives After reviewing this chapter readers should be able to: • Describe the steps of the research process and key components of designing a study. • Explain that the conceptual phase, including a conceptual or theoretical framework,

ACCORD Lipid trial - Summary & Results - fr.slideshare.net
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