Redox study glutamine results

A Randomized Trial of Glutamine and Antioxidants in ...

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The rationale for our study design reflected the view that glutamine is essential in critical illness because of rapid depletion of plasma glutamine levels; furthermore, lower plasma glutamine ...

A Randomized Trial of Glutamine and Antioxidants in ...

The effect of glutamine therapy on outcomes in critically ...

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1/9/2014 · Glutamine supplementation is supposed to reduce mortality and nosocomial infections in critically ill patients. However, the recently published reducing deaths due to oxidative stress (REDOX) trials did not provide evidence supporting this. This study investigated the impact of glutamine ...

The effect of glutamine therapy on outcomes in critically ...

A Randomized Trial of Glutamine and Antioxidants in ...

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The new england journal of medicine n engl j med 368;16 nejm.org april 18, 2013 1489 original article A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients Daren Heyland, M.D ...

A Randomized Trial of Glutamine and Antioxidants in ...

A randomized trial of glutamine and antioxidants in ...

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4/18/2013 · There were no differences among the groups with respect to serious adverse events (P=0.83). CONCLUSIONS: Early provision of glutamine or antioxidants did not improve clinical outcomes, and glutamine was associated with an increase in mortality among critically ill …

A randomized trial of glutamine and antioxidants in ...

Trial of Glutamine and Antioxidant Supplementation in ...

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Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients (REDOXS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

Trial of Glutamine and Antioxidant Supplementation in ...

Trial of Glutamine and Antioxidant Supplementation in ...

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8/24/2005 · The results of two separate meta-analyses suggested that glutamine and antioxidants may be associated with improved survival. We have recently completed a dosing study to determine the maximal tolerable dose (MTD) of glutamine dipeptides and antioxidants in critically ill patients with evidence of hypoperfusion.

Trial of Glutamine and Antioxidant Supplementation in ...

Glutamine and glutathione at ICU admission in relation to ...

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6/1/2012 · Glutamine depletion is demonstrated to be an independent predictor of hospital mortality in ICU (intensive care unit) patients. Today glutamine supplementation is recommended to ICU patients on parenteral nutrition. In addition to glutamine, glutathione may be a limiting factor in ICU patients with MOF (multiple organ failure). To study the prevalence of glutamine and glutathione depletion an ...

Glutamine and glutathione at ICU admission in relation to ...

Lymphocyte proliferation modulated by glutamine: involved ...

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Glutamine is not only an important energy source in mitochondria, but is also a precursor of glutamate, which is used for cellular glutathione (GSH) biosynthesis in lymphocytes. In this study, we investigated the effects of glutamine on the redox reaction during lymphocyte proliferation.

Lymphocyte proliferation modulated by glutamine: involved ...

Enteral glutamine supplementation in critically ill ...

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8/4/2015 · Glutamine (GLN) has been suggested to have a beneficial influence on outcomes of critically ill patients. However, recent large-scale trials have suggested harm associated with GLN supplementation. Recently, systematic reviews on the use of parenteral GLN have been published; however, less information is available on the role of enteral GLN.

Enteral glutamine supplementation in critically ill ...

l -Glutamine Attenuates Apoptosis in Porcine Enterocytes ...

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4/11/2018 · Of interest, the 4-HNE–induced upregulation of AKR1C1, instead of AKR1A1, was upregulated by l-glutamine supplementation, indicating a potential role of AKR1C1 in the protective effect of l-glutamine. In conclusion, the results from the present study demonstrated that 4-HNE, a lipid peroxidation endproduct, induced cell injury and activation ...

l -Glutamine Attenuates Apoptosis in Porcine Enterocytes ...

(PDF) Consequences of the REDOXS and METAPLUS Trials: The ...

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PDF | On Jan 7, 2015, Arthur R H van Zanten and others published Consequences of the REDOXS and METAPLUS Trials: The End of an Era of Glutamine and Antioxidant Supplementation for Critically Ill ...

(PDF) Consequences of the REDOXS and METAPLUS Trials: The ...

Glutamine and glutathione at ICU admission in relation to ...

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Glutamine and glutathione at ICU admission in relation to outcome Paul Castillo RODAS, Olav ROOYACKERS, Christina HEBERT, A˚ke NORBERG and ... glutathione depletion an observational study was performed. The results were analysed in relation ... glutathione redox status was also an independent mortality predictor, but here a ...

Glutamine and glutathione at ICU admission in relation to ...

L-Glutamine therapy reduces endothelial adhesion of sickle ...

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7/25/2005 · On the basis of these results, we proceeded to study the effect of L-glutamine therapy on endothelial adhesion of sickle RBC. As noted in the data presented here, in both cross-sectional and longitudinal studies, there is an indication that L-glutamine therapy improves the endothelial adhesion of …

L-Glutamine therapy reduces endothelial adhesion of sickle ...

Role of Glutamine Supplementation in Critical Illness ...

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Request PDF on ResearchGate | On May 2, 2013, Daren K Heyland and others published Role of Glutamine Supplementation in Critical Illness Given the Results of the REDOXS Study

Role of Glutamine Supplementation in Critical Illness ...

Regulation of stem-like cancer cells by glutamine through ...

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2/28/2017 · The results of our study suggest that a mechanism by which glutamine affects SP cells may be through ROS-mediated activation of the β-catenin pathway, ... Glutamine is a precursor for glutamine synthesis and is important in maintaining redox balance. Depletion of glutamine would result in a decrease in GSH, and subsequently causes an ...

Regulation of stem-like cancer cells by glutamine through ...

The influence of parenteral glutamine supplementation on ...

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Supplementation of glutamine was performed according to ESPEN guidelines for ICU patients with a grade A recommendation for 0.4–0.6 g/kg/day of alanyl-glutamine dipeptide. Despite the results of the REDOX study, our results suggest that in trauma patients with one- or two-organ dysfunction related to the injury rather than sepsis or infection ...

The influence of parenteral glutamine supplementation on ...

Redox control of glutamine utilization in cancer | Cell ...

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12/4/2014 · Redox control of glutamine utilization in cancer. ... results in an enhanced lipid ... a genome-wide study of the Warburg effect that links metabolic steps to cancer cell migration 101 and a ...

Redox control of glutamine utilization in cancer | Cell ...

HIF-1a Promotes Glutamine-Mediated Redox Homeostasis and ...

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In the present study we question whether and how hypoxic preconditioning of skeletal cells affects bone regeneration. We demonstrate that inactivation of PHD2 in skeletal cells prior to implantation increases HIF-1a signaling and improves cell sur-vival, notby enhancing angiogenesis, but by adapting glutamine and glucose metabolism.

HIF-1a Promotes Glutamine-Mediated Redox Homeostasis and ...

Glutamine - an overview | ScienceDirect Topics

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Further study demonstrated that glutamine induces proliferation of oTr1 cells via hexosamine-mediated activation of the TSC2-mTOR cell signaling pathway (X. Wang, G. Wu, and F.W. Bazer, unpublished results). Moreover, glutamine is required to facilitate the uptake of …

Glutamine - an overview | ScienceDirect Topics

Phase 3 Study of L-Glutamine Therapy in Sickle Cell Anemia ...

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12/2/2016 · A Phase 2 study of Pharmaceutical Grade L-glutamine (L-glutamine) versus placebo showed promising results on clinical endpoints. In a Phase 3 study with 230 SCD patients, randomized 2:1 to L-glutamine or placebo, the median number of SCCs was 25% lower for L-glutamine than placebo (L-glutamine 3.0 vs. placebo 4.0).

Phase 3 Study of L-Glutamine Therapy in Sickle Cell Anemia ...

Glutamine-driven oxidative phosphorylation is a major ATP ...

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glutamine-driven oxidative phosphorylation is a major ATP source even in oncogene-expressing or hypoxic cells. Results and discussion Quantifying ATP production routes via a redox-balanced metabolic flux model To study ATP production routes, we used Bax /, Bak murine renal epithelial cells immortalized by expression of

Glutamine-driven oxidative phosphorylation is a major ATP ...

Real-time imaging of the intracellular glutathione redox ...

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5/11/2008 · Conventional redox-sensitive GFPs (roGFPs) are limited by undefined specificity and slow response to changes in redox potential. In this study we demonstrate that …

Real-time imaging of the intracellular glutathione redox ...

Regulation of stem-like cancer cells by glutamine through ...

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Results: We show that glutamine supports the maintenance of the stem cell phenotype by promoting glutathione synthesis and thus maintaining redox balance for SP cells. A deprivation of glutamine in the culture medium ... tion (SP) cells as our in vitro model to study the poten-tial impact of glutamine on stem-like cancer cells. Glutamine ...

Regulation of stem-like cancer cells by glutamine through ...

Glutathione - Wikipedia

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Glutathione inhibits the actual production as well as agglutination of melanin by interrupting the function of L-DOPA. Another study found that glutathione inhibits melanin formation by direct inactivation of the enzyme tyrosinase by binding and chelating copper within the enzyme's active site.

Glutathione - Wikipedia

Metabolic Fate of Oral Glutamine Supplementation within ...

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11/19/2010 · Methods: We performed pK studies to determine the metabolic fate of glutamine supplementation on plasma and erythrocyte amino acids in patients with SCD. Patients fasting for > 8 hours received 10 grams of L-glutamine powder mixed with Gatorade. Blood was analyzed at baseline, 30, 60, 90, 2hr, 3hr, 4hr and 8hrs after ingesting study drug.

Metabolic Fate of Oral Glutamine Supplementation within ...

Redox regulation of carbon storage and partitioning in ...

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phase 3 study, n=230 and a phase 2 study, n=70). In these trials , patients with sickle cell anemia or ... L-glutamine may improve the NAD redox potential in sickle RBCs through increasing the availability of reduced glutathione. ... Relevant results from published literature are summarized below.

Redox regulation of carbon storage and partitioning in ...

ENDARI (L-glutamine oral powder ) To report SUSPECTED ...

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727 alone consumed 60ml olive oil (labeled with 20MBq 99mTc-V-thiocyanate) and 300ml water containing 75g glucose (labeled with 6MBq 67Ga-EDTA), on 2 separate days, with and Glutamine Prevents Cytokine-lndueed Apoptosis and Oxidation of Glutathione without 120rag orlistat, while lying in the left lateral decubitus position against a gamma Redox in HT-29 Cells camera.

ENDARI (L-glutamine oral powder ) To report SUSPECTED ...

(PDF) Glutamine prevents cytokine-induced apoptosis and ...

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7/24/2018 · The study showed that whether administered alone or with hydroxyurea, L-glutamine reduced the frequency of sickle cell pain crises by 25 percent (a median of three events per patient in the L-glutamine group and four in the placebo group) and hospitalizations by 33 percent (a median of two hospitalizations in the L-glutamine group and three in ...

(PDF) Glutamine prevents cytokine-induced apoptosis and ...

New Study Shows L-Glutamine Decreases Sickle Cell Pain ...

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tumors. In a recent study,4 we used an Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance Costas a. Lyssiotis,1 Jaekyoung son,2 Lewis C. Cantley1,* and alec C. Kimmelman2,*

New Study Shows L-Glutamine Decreases Sickle Cell Pain ...

Pancreatic cancers rely on a novel glutamine metabolism ...

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Effect of Glutamine Supplementation in Patients with Inflammatory Bowel Diseases. Nutri Food Sci Int J. 2016; 1(5): 555574. DOI: 10.19080/NFSIJ.2016.01.555574 002 Nutrition & Food Science International Journal associated with inhibition of nuclear factor-κB and p38 mitogen-activated protein kinase in the intestinal mucosa by glutamine

Pancreatic cancers rely on a novel glutamine metabolism ...

Effect of Glutamine Supplementation in Patients with ...

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Learn more about Glutamine uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Glutamine

Effect of Glutamine Supplementation in Patients with ...

Glutamine: Uses, Side Effects, Interactions, Dosage, and ...

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Although there are many technical differences between our study and their study that could account for this discrepancy, even beyond tumor cell of origin and implantation site, both their and our in vivo tracing studies found that less than 3% of the 2HG pool is labeled …

Glutamine: Uses, Side Effects, Interactions, Dosage, and ...

Transaminase Inhibition by 2-Hydroxyglutarate Impairs ...

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Oral L-glutamine NDA 208 587 ... L-glutamine, normalized NAD redox potential ... Phase 2 Efficacy Results Study 10478 L-glutamine N=37 Placebo N=33 Sickle Cell Crisisa

Transaminase Inhibition by 2-Hydroxyglutarate Impairs ...

Oral L-glutamine NDA 208 587

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Glutamine Addiction and Therapeutic Strategies in ... It plays also an important role in the redox homeostasis, and last but not least, upon conversion to -ketoglutarate, glutamine is an energy and anaplerotic carbon source that replenishes tricarboxylic ... coupled to the import of essential amino acids such as leucine, results in the ...

Oral L-glutamine NDA 208 587

Glutamine Addiction and Therapeutic Strategies in Lung Cancer

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Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells ... to perturbation of the redox balance and decreased viability of cocultured neurons. GS inhibition also decreases ... present study shows for the first time a metabolic mechanism mediating microglial response to a proin-

Glutamine Addiction and Therapeutic Strategies in Lung Cancer

Blockade of Glutamine Synthetase Enhances Inflammatory ...

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This study investigated the effect of N-acetyl-cysteine (NAC) supplementation through drinking water on animal performance and the glutathione (GSH) redox system in weaned piglets, particularly in relation to the immediate post-weaning feed intake. To this end, 168 piglets were weaned and either fed ad libitum or fasted the first two days, and either or not administered 200 mg/L NAC via the ...

Blockade of Glutamine Synthetase Enhances Inflammatory ...

Effects of N-Acetyl-Cysteine Supplementation through ...

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11/18/2016 · Here we used HCV‐infected cells and liver biopsies to study how HCV modulates the glutaminolysis pathway, which is known to play an important role in cellular energetics, stress defense, and neoplastic transformation. ... and these have presented contradictory results. 7, ... it is required for glutathione synthesis and redox homeostasis. 10 ...

Effects of N-Acetyl-Cysteine Supplementation through ...

Hepatitis C virus infection triggers a tumor‐like ...

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Recent discoveries in cancer biology have placed amino acids generally, and glutamine specifically, in central roles for biosynthesis, cellular energetics, and redox homeostasis. 15 –18 In the present study, we sought to examine glutamine metabolism in PAH in the specific context of dysfunctional signaling through bone morphogenic protein ...

Hepatitis C virus infection triggers a tumor‐like ...

Dysfunctional BMPR2 signaling drives an abnormal ...

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3/10/2017 · Results: GS inhibition enhances release of inflammatory mediators of LPS-activated microglia in vitro, leading to perturbation of the redox balance and decreased viability of cocultured neurons. GS inhibition also decreases insulin-mediated glucose uptake in microglia.

Dysfunctional BMPR2 signaling drives an abnormal ...
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