Woscops statin study

WOSCOPS at 20 Years Shows 'Lifetime' Benefit of Statins

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WOSCOPS, a primary-prevention study with 6595 men aged 45 to 64 years with elevated cholesterol levels, was one of the pioneering statin-therapy trials when it was published in 1995.

WOSCOPS at 20 Years Shows 'Lifetime' Benefit of Statins

Prevention of Coronary Heart Disease with Pravastatin in ...

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Background Lowering the blood cholesterol level may reduce the risk of coronary heart disease. This double-blind study was designed to determine whether the administration of pravastatin to men ...

Prevention of Coronary Heart Disease with Pravastatin in ...

Long-Term Follow-up of the West of Scotland Coronary ...

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The West of Scotland Coronary Prevention Study (WOSCOPS) ... There were more cases of prostate cancer in the placebo group than in the statin group. The LIPID Study Group reported results 7 for a ...

Long-Term Follow-up of the West of Scotland Coronary ...

West Of Scotland Coronary Prevention Study WOSCOPS

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WOSCOPS Figure 1.2 Figure 1.1 Major primary prevention Evidence & Efficacy: Lipid-Modifying Therapy trials with statins West Of Scotland Coronary Prevention Study Reference Shepherd et al., for the West of Scotland Coronary Prevention Study Group (1995) Prevention of coronary heart disease with

West Of Scotland Coronary Prevention Study WOSCOPS

Long-Term Safety and Efficacy of Lowering Low-Density ...

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Background—Extended follow-up of statin-based low-density lipoprotein cholesterol lowering trials improves the understanding of statin safety and efficacy. Examining cumulative cardiovascular events (total burden of disease) gives a better appreciation of the clinical value of statins. This article evaluates the long-term impact of therapy on mortality and cumulative morbidity in a high-risk ...

Long-Term Safety and Efficacy of Lowering Low-Density ...

The 'New Study' Showing Everyone Needs Statins - STATIN NATION

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9/29/2017 · The WOSCOPS study included 6,595 men in the West of Scotland, with high cholesterol levels. During this five year study, 1.7% of people who were given the placebo died of heart disease, compared with 1.2% of those who were given the statin. And overall, the use of the statin increased the chances of still being alive after 5 years, from a 96% ...

The 'New Study' Showing Everyone Needs Statins - STATIN NATION

Long-Term Safety and Efficacy of Lowering Low-Density ...

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3/15/2016 · Long-Term Safety and Efficacy of Lowering Low-Density Lipoprotein Cholesterol With Statin Therapy ... trial. 7–11 In the West of Scotland Coronary Prevention Study (WOSCOPS), ... for every new case of diabetes mellitus. 36 In this study, we were able to report that statin treatment was also associated over a 20-year follow-up with ...

Long-Term Safety and Efficacy of Lowering Low-Density ...

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WOSCOPS | definition of WOSCOPS by Medical dictionary

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White said, but the key to why the legacy effect was seen in WOSCOPS despite the use of pravastatin--a less-potent statin--but not to date in other statin trials may lie in the fact that WOSCOPS was a primary prevention study and its participants had the youngest mean age of all the major statin trials.

WOSCOPS | definition of WOSCOPS by Medical dictionary

Serious bias in 20 year follow-up study of statin trial ...

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10/31/2017 · The BMJ ’s news story on the follow-up study of the WOSCOPS trial says that total and cardiovascular mortality were considerably reduced in men allocated to the treatment group at 20 year follow-up; in particular among those with the highest concentrations of low density lipoprotein (LDL) cholesterol.12 But the study has serious bias. …

Serious bias in 20 year follow-up study of statin trial ...

Protecting the Heart: A Practical Review of the Statin Studies

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The next major study, [5] chronologically, was WOSCOPS. This addressed a different question from 4S and investigated whether hypolipidemic therapy was beneficial in hypercholesterolemic men ...

Protecting the Heart: A Practical Review of the Statin Studies

WOSCOPS: Lifetime Clinical and Economic Benefits of Statin ...

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11/18/2014 · While the initial WOSCOPS trial looked at 6,595 men who were randomized to 40mg/d of pravastatin or placebo, the 20-year follow-up study, led by Chris J. Packard, MD, University of Glasgow, examined the long-term (lifetime) clinical and economic benefits of statin-based LDL lowering.

WOSCOPS: Lifetime Clinical and Economic Benefits of Statin ...

Statins and the risk of type 2 diabetes mellitus: cohort ...

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7/15/2014 · There is strong evidence of reductions in major vascular events from statins across all cardiovascular risk categories. However, trials of statin therapy have provided conflicting results regarding statin use and type 2 diabetes (T2DM). We aimed to assess the effect of statins on T2DM development. We carried out a population-based cohort study using the Clinical Practice Research Datalink ...

Statins and the risk of type 2 diabetes mellitus: cohort ...

Statin Therapy and Risk of Developing Type 2 Diabetes: A ...

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10/1/2009 · OBJECTIVE Although statin therapy reduces cardiovascular risk, its relationship with the development of diabetes is controversial. The first study (West of Scotland Coronary Prevention Study [WOSCOPS]) that evaluated this association reported a small protective effect but used nonstandardized criteria for diabetes diagnosis. However, results from subsequent hypothesis-testing trials have been ...

Statin Therapy and Risk of Developing Type 2 Diabetes: A ...

lowering patients coronary heart Scandinavian Simvastatin ...

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1383 Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S) Summary Drug therapy for hypercholesterolaemia has remained controversial mainly because of insufficient clinical trial evidence for improved survival.The present trial was designed to evaluate the effect of cholesterol lowering with

lowering patients coronary heart Scandinavian Simvastatin ...

Statins reduce deaths from coronary heart disease by 28 ...

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9/6/2017 · Imperial College London. (2017, September 6). Statins reduce deaths from coronary heart disease by 28 per cent in men, according to longest ever study. ScienceDaily. Retrieved April 8, …

Statins reduce deaths from coronary heart disease by 28 ...

Low-Density Lipoprotein Cholesterol Lowering for the ...

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Background:Patients with primary elevations of low-density lipoprotein cholesterol (LDL-C) ≥190 mg/dL are at a higher risk of atherosclerotic cardiovascular disease as a result of long-term exposure to markedly elevated LDL-C levels. Therefore, initiation of statin therapy is recommended for these individuals. However, there is a lack of randomized trial evidence supporting these ...

Low-Density Lipoprotein Cholesterol Lowering for the ...

Exaggerated report of benefits in a flawed long term ...

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10/31/2017 · The BMJ reports on the findings of a study on long term (20 year) treatment with a statin in the WOSCOPS trial by Vallejo-Vaz et al.12 The news article and publication report that, in this primary prevention trial, pravastatin reduced deaths from heart disease by 28% in men with high levels of LDL cholesterol. But 28% …

Exaggerated report of benefits in a flawed long term ...

Articles Telomere length, risk of coronary heart disease ...

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Study (WOSCOPS) who went on to develop coronary heart disease events with those from 1058 matched controls who remained event free. We also investigated whether there was any association between telomere length and observed clinical benefi t of statin treatment in WOSCOPS.

Articles Telomere length, risk of coronary heart disease ...

WOSCOPS - West of Scotland Coronary Prevention Study ...

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Research on KIF6 The association between KIF6 and event reduction during pravastatin (Pravachol[R]) therapy has been demonstrated in three prospective, placebo-controlled randomized clinical trials of statin therapy for the prevention of CHD events: the secondary prevention Cholesterol and Recurrent Events (CARE) study; the primary prevention West of Scotland Coronary Prevention Study …

WOSCOPS - West of Scotland Coronary Prevention Study ...

Statin therapy and risk of developing type 2 diabetes: a ...

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Study [WOSCOPS]) that evaluated this association reported a small protective effect but used nonstandardized criteria for diabetes diagnosis. However, results from subsequent hypothesis-testing trials have been inconsistent. The aim of this meta-analysis is to evaluate the possible effect of statin therapy on incident diabetes.

Statin therapy and risk of developing type 2 diabetes: a ...

Long-term impact on healthcare resource utilization of ...

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aims of this study were to determine whether cardiac troponin I concentrations could predict future coro-nary events, be modified by statins, and assess response to therapy in WOSCOPS. METHODS STUDY POPULATION.WOSCOPS randomized 6,595 men ages 45 to 64 years with moderate hypercholes-terolemia (LDL cholesterol concentrations 152 to 228

Long-term impact on healthcare resource utilization of ...

High-Sensitivity Cardiac Troponin, Statin Therapy, and ...

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WOSCOPS West of Scotland Coronary Prevention Study Introduction Statin treatmentiseffective inthe primary and secondary pre-ventionofcardiovasculardisease(CVD)eventsinindividuals withandwithoutdiabetes[1,2]andisgenerallysafeandwell tolerated [2]. In the West of Scotland Coronary Prevention Study (WOSCOPS) pravastatin treatment decreased the risk

High-Sensitivity Cardiac Troponin, Statin Therapy, and ...

Increased risk of diabetes with statin treatment is ...

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Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. 1 A challenge in reducing adverse outcomes of CVD is that the first clinical manifestation can be catastrophic, including sudden cardiac death, acute myocardial infarction, or stroke. 2, 3 Statins reduce the risk of CVD-associated morbidity and mortality through their effects on lipids and are ...

Increased risk of diabetes with statin treatment is ...

Evidence Summary: Statins for Prevention of Cardiovascular ...

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Cholesterol lowering with statins: How WOSCOPS ... Pioneering studies such as the Framingham Study and MR FIT identified high blood cholesterol as a risk factor for cardiovascular disease. However, because total cholesterol (TC) ≤300mg/dL was common physicians were not convinced that this was abnormal. ... In 1987, the first statin arrived ...

Evidence Summary: Statins for Prevention of Cardiovascular ...

Cholesterol lowering with statins: How WOSCOPS confounded ...

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ing vascular disease. Prior to this study, lower cholesterol levels in the elderly were thought to be associated with increased mortality. In the PROSPER study, patients were treated with a low potency statin (pravastatin 40mg daily). After 3.2 years there was a …

Cholesterol lowering with statins: How WOSCOPS confounded ...

healthcare professionals Best Practice statins in older ...

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The appearance of statins was key to our understanding of the pathologic effects of hypercholesterolemia. Before statins were available, physicians did not know whether cholesterol lowering improved cardiovascular health.Pioneering studies such as the Framingham Study and MR FIT identified high blood cholesterol as a risk factor for cardiovascular disease.

healthcare professionals Best Practice statins in older ...

Cholesterol lowering with statins: How WOSCOPS confounded ...

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5/15/2015 · ACCEL | The West of Scotland Coronary Prevention Study (WOSCOPS) was the first major primary prevention trial of statin therapy, composed of 6,595 men with hypercholesterolemia (total cholesterol of 272 ± 23 mg/dL, considered “moderate” hypercholesterolemia in 1989) and no history of myocardial infarction (MI). Participants were randomized to pravastatin (40 mg) or placebo for five years.

Cholesterol lowering with statins: How WOSCOPS confounded ...

Long-term Follow-up of Statin Prevention Study: Instead of ...

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Although statin therapy reduces cardiovascular risk, its relationship with the development of diabetes is controversial. The first study (West of Scotland Coronary Prevention Study [WOSCOPS]) that ...

Long-term Follow-up of Statin Prevention Study: Instead of ...

Statin Therapy and Risk of Developing Type 2 Diabetes: A ...

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Methods WOSCOPS (West of Scotland Coronary Prevention Study) randomized men with raised low-density lipoprotein cholesterol and no history of myocardial infarction to pravastatin 40 mg once daily or placebo for 5 years. Plasma cardiac troponin I concentration was measured with a high-sensitivity assay at baseline and at 1 year in 3,318 participants.

Statin Therapy and Risk of Developing Type 2 Diabetes: A ...

High-Sensitivity Cardiac Troponin, Statin Therapy, and ...

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1/19/2007 · Methods. We compared telomere lengths at recruitment in 484 individuals in the West of Scotland Primary Prevention Study (WOSCOPS) who went on to develop coronary heart disease events with those from 1058 matched controls who remained event free.

High-Sensitivity Cardiac Troponin, Statin Therapy, and ...

Telomere length, risk of coronary heart disease, and ...

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It was known as the West of Scotland Coronary Prevention Study (WOSCOPS), and it was the first trial to demonstrate a significant reduction in cardiovascular events with statin therapy for primary prevention. The critical report challenging the BMJ’s statin-promotion based on the WOSCOPS study was published recently, October of 2017.

Telomere length, risk of coronary heart disease, and ...

Statin - Coconut Oil

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Statin - Coconut Oil

WOSCOPS 20-Year Follow-Up Shows Impressive Statin ‘Legacy ...

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At that point, WOSCOPS leaders advised study participants' primary care physicians to seriously consider putting their patients on long-term statin therapy. However, only an identically low 31% of subjects in each of the two study arms did so.

WOSCOPS 20-Year Follow-Up Shows Impressive Statin ‘Legacy ...

WOSCOPS: statin 'legacy effect' stands 20 years. - Free ...

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Among men with very high LDL followed for 20 years, use of a low-intensity statin conferred reduced risk for CHD, CV and all-cause mortality, according to new data from the WOSCOPS study.

WOSCOPS: statin 'legacy effect' stands 20 years. - Free ...

WOSCOPS: Statins reduce mortality in men with very high ...

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The critical report challenging the BMJ’s statin-promotion based on the WOSCOPS study was published recently, October of 2017. The challenging trio of medical scientists, led by independent researcher Uffe Ravnskov MD, PhD, author of The Cholesterol Myth and Fat and Cholesterol are Good for You, parsed and picked at the study to show it is flawed.

WOSCOPS: Statins reduce mortality in men with very high ...

Medical Promotion of Cholesterol-lowering Drugs Biased ...

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• Overview of Basic Study Design and Biostatistics • Prominent Landmark Clinical Trials: – Statin trials – LDL-C focused nonstatin trials – Mixed lipid modification focused nonstatin trials – Triglyceride/HDL-C focused nonstatin trials • Other Landmark Trials • Trials on the Horizon 3

Medical Promotion of Cholesterol-lowering Drugs Biased ...
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